Phosphorylation of IÎ✫ and IKK was significantly (p pomegranate inhibits inflammation, as well as amyloidogenesis in IL-1β-stimulated SK-N-SH cells. PWE (25-200 μg/ml) dose dependently reduced COX-2-dependent PGE2 production in SK-N-SH cells stimulated with IL-1β. Levels of BACE-1 and Aβ in SK-N-SH cells stimulated with IL-1β were measured with an in cell ELISA. Expression of COX-2, phospho-IÎ✫, and phospho-IKK proteins was evaluated, while NF-Î✫ reporter gene assay was carried out in TNFα-stimulated HEK293 cells to determine the effect of PWE on NF-Î✫ transactivation. An enzyme immunoassay (EIA) was used to measure prostaglandin E2 (PGE2) production from supernatants of IL-1β-stimulated SK-N-SH cells. In this study, we aimed to assess the effects of freeze-dried pomegranate (PWE) on PGE2 production in IL-1β-stimulated SK-N-SH cells. (Punicaceae), and its constituents have been shown to inhibit inflammation. Velagapudi, Ravikanth Baco, Gina Khela, Sunjeet Okorji, Uchechukwu Olajide, Olumayokun Pomegranate inhibits neuroinflammation and amyloidogenesis in IL-1β-stimulated SK-N-SH cells.
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